Clomiphene

Clomiphene is a selective estrogen receptor modulator (SERM) approved to induce ovulation. Endocrine protocols and protocols related to testosterone replacement also use it off-label.

• Hormonal Regulation

  Most effective

  Direct endocrine activity produces well-characterized hormonal effects.

• Reproductive Health

  Effective

  Fertility care and reproductive medicine are areas of research and clinical use.

• Metabolic Support

  Moderate

  Hormonal pathways may produce additional effects on metabolism.

• Other medications

  Caution

  Consult your prescriber before combining with any medication.

• BPC-157

  Compatible

• NAD+

  Compatible

• Vitamin D

  Compatible

Diluent: Use bacteriostatic water only. Avoid saline because it can cause precipitation.

1. Take the Clomiphene vial out of refrigeration and wait 15–20 minutes for it to reach room temperature.
2. Disinfect the rubber stopper with an alcohol swab, then let it dry fully in the air.
3. Use a sterile syringe to measure the calculated amount of bacteriostatic water. Use BAC water only; avoid saline because precipitation can occur.
4. Direct the water slowly onto the inner vial wall rather than onto the powder.
5. Rotate the vial gently to mix. Never shake it vigorously; this can degrade the peptide.
6. Wait 2–3 minutes for complete dissolution, and check that the liquid is transparent and colorless.
7. Measure your calculated dose into an insulin syringe for a subcutaneous injection.
8. Choose the abdomen, thigh or upper arm for injection. Change the site each time to help prevent lipodystrophy.
9. Refrigerate the mixed vial at 2–8 °C and use it within 28 days.

Week 1–2

Early effects may emerge during adaptation. Watch for adverse reactions.

Week 2–4

The main effects may start to appear. Change dosing only as your provider recommends.

Week 4–8

The principal effects are expected to be apparent by this stage. Review progress with your provider.

Week 8+

Review the outcome with your provider and decide whether to continue, cycle treatment or adjust the dose.

• Redness, bruising or slight pain at an injection site
• Possible allergic reactions; stop use if hives or a rash develop
• Responses differ between individuals; begin with the lowest dose and observe your response carefully
• Speak with your healthcare provider before use and report unexpected symptoms

Clomiphene: approved in the US.

• US

  Approved

  FDA — approved specifically for ovulation induction; endocrine and testosterone-related uses are off-label. No 503A ban is recorded; affirmative compounding authorization remains unestablished.

  Rx required

  Yes

  Telehealth

  Available

1. Clomiphene citrate for male hypogonadism and infertility: a review (2012)

2. Anabolic steroid-induced hypogonadism: diagnosis and treatment. (2014)

   PMID 24636400DOI 10.1016/j.fertnstert.2014.02.002

3. Therapeutic management in women with a diminished ovarian reserve: a systematic review and meta-analysis of randomized controlled trials. (2025)

   PMID 39332623DOI 10.1016/j.fertnstert.2024.09.038