Glutathione

Glutathione is an antioxidant made naturally in the body from three amino acids. It appears in clinical protocols as well as wellness applications. Investigations include aging and cellular processes, but these interests do not by themselves establish an effective treatment for those conditions.

• Cellular Longevity

  Moderate

  Investigations examine telomere length and processes involved in cellular senescence.

• Hormonal Balance

  Moderate

  Potential effects concern endocrine changes that accompany increasing age.

• Cognitive Aging

  Limited

  Preliminary investigations address preservation of cognition as people age.

• Medications

  Caution

  Consult your prescriber before combining this compound with any medication.

• BPC-157

  Compatible

• NAD+

  Compatible

• Vitamin D

  Compatible

Diluent: Use bacteriostatic water only; avoid saline because precipitation can occur.

1. Let the refrigerated vial warm to room temperature for 15–20 minutes before preparing it.
2. Disinfect the stopper using an alcohol swab, then wait until the surface has dried fully in the air.
3. Use a sterile syringe to measure your calculated amount of bacteriostatic water. Use this diluent only; avoid saline because precipitation may occur.
4. Introduce the water gradually against the inner glass wall. Keep the stream away from the peptide powder itself.
5. Rotate the vial gently to mix its contents. Do not shake forcefully, because vigorous agitation can degrade the peptide.
6. Wait 2–3 minutes for the powder to dissolve completely. Check that the liquid is transparent and has no color.
7. Measure your calculated dose with an insulin syringe in preparation for administration beneath the skin.
8. Use the abdomen, thigh or upper arm for subcutaneous administration. Change the injection location each time to help prevent lipodystrophy.
9. Return the mixed vial to refrigeration at 2–8°C. Use the prepared solution within 28 days of mixing.

Week 1–2

Early effects may accompany an adjustment period. Watch for any unwanted reaction as you adapt.

Week 2–4

The principal effects may begin emerging. Follow your clinician’s recommendations for any change in dose.

Week 4–8

Main effects are expected to be apparent at this stage. Review your progress together with your clinician.

Week 8+

Review the outcome with your clinician and decide whether to continue, take a cycle break or adjust the dose. These timings do not establish effectiveness for every compound.

• Bruising, redness or mild soreness where the injection is given
• Possible allergic response; stop use if you develop hives or a rash
• Variable individual response; begin with the lowest dose and watch closely for reactions
• Discuss use with your clinician beforehand and report symptoms that are unusual for you

Glutathione: not approved in the US.

• US

  Not approved

  FDA — no product approval is established here. The regulatory category is clinical and compoundable, with no 503A ban and telehealth availability.

  Rx required

  No

  503A

  Allowed

  Telehealth

  Available

1. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. (2015)

   PMID 24791752DOI 10.1007/s00394-014-0706-z

2. Intravenous glutathione for skin lightening: Inadequate safety data. (2016)

   PMID 27499402DOI 10.7196/SAMJ.2016.v106i8.10878

3. Dietary glutathione supplementation enhances antioxidant activity and protects against lipopolysaccharide-induced acute hepatopancreatic injury and cell apoptosis in Chinese mitten crab, Eriocheir sinensis. (2020)

   PMID 31857224DOI 10.1016/j.fsi.2019.12.049

4. Glutathione and Selenium Supplementation Attenuates Liver Injury in Diethylnitrosamine-Induced Hepatocarcinogenic Mice by Enhancing Glutathione-Related Antioxidant Capacities. (2024)

   PMID 39518894DOI 10.3390/ijms252111339