L-Carnitine

L-Carnitine is derived from an amino acid and is not a peptide. Its uses concern mitochondrial function and metabolic support. Supplement and prescription formulations exist, with availability depending on the formulation and applicable rules.

Research schedules name a low starting amount and a titrated standard amount without numeric doses. Frequency depends on the protocol, and the route varies.

Start with the lowest dose, monitor your response and report unusual symptoms to your clinician.

• Cellular Longevity

  Moderate

  Investigations assess telomere length and the processes associated with cellular senescence.

• Hormonal Balance

  Moderate

  Potential hormonal effects are being considered in the context of aging.

• Cognitive Aging

  Limited

  Preliminary investigations address preservation of cognition as people age.

• Medications

  Caution

  Ask your prescriber to review any medication before combining treatments.

• BPC-157

  Compatible

• NAD+

  Compatible

• Vitamin D

  Compatible

Diluent: Use bacteriostatic water; avoid saline because precipitation may occur.

1. Let the refrigerated vial stand at room temperature for 15–20 minutes before preparation.
2. Disinfect the stopper using an alcohol swab, then wait until it has dried fully in the air.
3. Measure the calculated quantity of bacteriostatic water with a sterile syringe. Use only this diluent; avoid saline because precipitation may occur.
4. Add the water gradually against the inner vial wall. Keep the stream away from the powder itself.
5. Rotate the vial with a gentle swirling motion. Do not shake forcefully, because this can degrade the contents.
6. Wait 2–3 minutes for the powder to dissolve completely, and check that the liquid is transparent and has no color.
7. Use an insulin syringe to withdraw the calculated amount for injection beneath the skin.
8. Inject in the thigh, abdomen or upper arm. Change the injection location each time to help prevent lipodystrophy.
9. Refrigerate the mixed solution at 2–8°C. Use it within a maximum of 28 days after preparation.

Week 1–2

During the first 1–2 weeks, early effects may accompany an adjustment period. Watch for adverse reactions.

Week 2–4

By weeks 2–4, the main effects may start becoming apparent. Make dose changes only according to your clinician’s guidance.

Week 4–8

During weeks 4–8, the principal effects are expected to be established. Review your progress with your clinician.

Week 8+

From week 8 onward, review the results and decide with your clinician whether to continue, cycle or change the dose.

• Mild pain, bruising or redness around the injection location
• Possible allergic reaction; stop use if hives or a rash develops

1. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. (2016)

   PMID 27335245DOI 10.1111/obr.12436

2. Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment. (2011)

   PMID 21929562DOI 10.1111/j.1365-2036.2011.04844.x

3. Propionyl-L-Carnitine in Ulcerative Colitis (NCT01026857) (2009)