Melanotan II

Melanotan II, also called MT-II, is a synthetic α-MSH analogue investigated for pigmentation, erectile responses and appetite reduction. Serious concerns include severe nausea, uncontrolled changes in melanocytes and moles, high blood pressure and priapism. FDA warnings have been issued repeatedly. It has no FDA approval, and 503A pharmacies cannot compound it. Exercise extreme caution.

Research schedules name a low starting amount and a titrated standard amount without numeric doses. Frequency depends on the protocol, and the route varies.

Responses differ between individuals. Begin with the lowest dose and observe your response carefully. Speak with your clinician before use and report unexpected symptoms. Human adverse effects are not fully characterized for every compound.

• Sexual Function

  Effective

  Research and clinical observations indicate effects on sexual responses.

• Libido Support

  Effective

  Clinical observations suggest improvements in measures of desire and arousal.

• Melanocortin Activity

  Moderate

  Its activity involves melanocortin receptors within the central nervous system.

• PDE5 Inhibitors (Sildenafil, Tadalafil)

  Monitor

• Blood Pressure Medications

  Caution

• Other Melanocortin Agonists

  Avoid

• Naltrexone

  Monitor

Diluent: Use bacteriostatic water; avoid saline because precipitation may occur.

1. Let the refrigerated vial stand at room temperature for 15–20 minutes before preparation.
2. Disinfect the stopper using an alcohol swab, then wait until it has dried fully in the air.
3. Measure the calculated quantity of bacteriostatic water with a sterile syringe. Use only this diluent; avoid saline because precipitation may occur.
4. Add the water gradually against the inner vial wall. Keep the stream away from the powder itself.
5. Rotate the vial with a gentle swirling motion. Do not shake forcefully, because this can degrade the contents.
6. Wait 2–3 minutes for the powder to dissolve completely, and check that the liquid is transparent and has no color.
7. Use an insulin syringe to withdraw the calculated amount for injection beneath the skin.
8. Inject in the thigh, abdomen or upper arm. Change the injection location each time to help prevent lipodystrophy.
9. Refrigerate the mixed solution at 2–8°C. Use it within a maximum of 28 days after preparation.

Week 1–2

During the first 1–2 weeks, early effects may accompany an adjustment period. Watch for adverse reactions.

Week 2–4

By weeks 2–4, the main effects may start becoming apparent. Make dose changes only according to your clinician’s guidance.

Week 4–8

During weeks 4–8, the principal effects are expected to be established. Review your progress with your clinician.

Week 8+

From week 8 onward, review the results and decide with your clinician whether to continue, cycle or change the dose.

• Mild pain, bruising or redness around the injection location
• Possible allergic reaction; stop use if hives or a rash develops

Melanotan II: not approved in the US; 503A compounding banned.

• US

  Not approved

  FDA: no approval for human treatment; research use only. Preparation by 503A compounding pharmacies is prohibited. Telehealth is not applicable.

  Rx required

  No

  503A

  Banned

  Telehealth

  N/A

1. Melanotan II and its molecular mechanisms (2009)

2. LC-HRMS characterization of the skin pigmentation and sexual enhancers melanotan II and bremelanotide sold on the black market of performance and image enhancing drugs. (2021)

   PMID 33245851DOI 10.1002/dta.2986

3. Melanotan II injection resulting in systemic toxicity and rhabdomyolysis. (2012)

   PMID 23121206DOI 10.3109/15563650.2012.740637